Saleem Ali Banihani
Jordan University of Science and Technology, Jordan
Title: Effect of urate, an end product of purine nucleosides catabolism, on sperm function
Biography
Biography: Saleem Ali Banihani
Abstract
Since beginning of the 60s, several studies have revealed the effect of urate, an end product of purine nucleosides catabolism, on semen quality and sperm function; though, this effect has not yet been collectively studied. Here, we systematically discuss the effect of urate on semen quality and sperm function and thus on sperm parameters (sperm motility, viability, morphology and sperm DNA oxidation). In conclusion, urate contributes to enhancing and protecting sperm viability, motility, morphology and sperm DNA damage, hence, contributes to protecting the ability of sperm to achieve fertilization. Mechanistically, this contribution is achieved primarily by counteracting the detrimental effect of nitrating agents and oxidizing agents, and enhancing the biochemical activity of certain enzymes in sperm. In contrast, high concentration of urate may induce negative effects on sperm parameters.