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5th World Congress on Epigenetics and Chromosome, will be organized around the theme “Shaping the future of Epigenetics and Genome Biology”

Epigenetics Congress 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Epigenetics Congress 2018

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Epigenetics is meant by the study of heritable changes in gene function without involving the changes in DNA arrangement. It mainly involves the changes in a chromosome which affects gene activity and functions, and also be used to report any heritable phenotypic change which does not derive from a modification of the genome. Epigenetics defined as the study of the epigenotype, which deals with the study of the properties of the pathways and processes that link the genotype and phenotype. A large number of diseases in humans such as cancer, metabolic syndromes and brain disorders have been related with irregularity in epigenetic processes. Process of cellular differentiation is the one of the example of an epigenetic change in eukaryotic biology.

  • Track 1-1Covalent modification
  • Track 1-2Nucleosome positioning
  • Track 1-3Transgenerational
  • Track 1-4Structural Inheritance
  • Track 1-5DNA damage

Epigenetic modifications are the cause for the disease developments, environmental exposure, drug treatment and aging. Epigenetic changes can be reversible and are potentially targeted by the pharmacological intervention. Epigenetic changes are the factors of human diseases, including Fragile X syndrome, Angelman’s syndrome, Prader-Willi syndrome, and various cancers. About 80% of brain disorders are related to multiple genomic defects in conjunction with environmental factors and epigenetic phenomena.The significant role of epigenetics in brain development and disease is due to the several factors like plasticity of epigenetics during all periods of brain development and aging as well as dynamic regulation in neurons.

  • Track 2-1Autosomal dominant polycystic kidney disease
  • Track 2-2Mitochondria diseases
  • Track 2-3Aneuploidy
  • Track 2-4Cardiovascular diseases
  • Track 2-5Nondisjunction

Cancer epigenetics is consider as the study of actual heritable changes to molecular processes which influence the flow of information between the DNA of cancer cells and their gene expression patterns. This includes comparison between tumor cell and normal cell and investigation of nuclear organization, DNA methylation, histone modification and the consequences of genetic mutations in genes encoding epigenetic regulators. DNA methylation patterns undergo complex changes in cancer. Many medicines which having a epigenetic impact are now used in several of diseases like cancer.

  • Track 3-1Histone modification
  • Track 3-2MicroRNA gene silencing
  • Track 3-3Prostate cancer
  • Track 3-4Cervical cancer
  • Track 3-5Epigenetic carcinogenic

Behavioral epigenetics is referring to the study the role of epigenetics in shaping animal and human behavior. It is an observational science that explores that how the nurture shapes the biological heredity, where nurture refers to virtually all things that occur during the life-span like social-experience, diet and nutrition, and exposure to toxins. Behavioral epigenetics is giving a structure to know about how the expression of genes is altered by experiences and environment for forming the differences in behavior, cognition, personality, and mental health of everyone.

  • Track 4-1Drug addiction
  • Track 4-2Psychopathy
  • Track 4-3Depressive disorder
  • Track 4-4Eating disorder
  • Track 4-5Social behavior of insects

Epigenetic and transgenerational epigenetic inheritance research are performed on a multiple number of mammal, insect, and plant. A lack of research into these topics using farm animal models (bovine, porcine, ovine, and gallus) exists. Research into epigenetic transgenerational inheritance is limited because much of the work has focused on the direct effects of environmental submission to toxicants and nutrients. Pesticides are the cause of having dramatic transgenerational epigenetic effects on many of the animal models which affecting the nervous system, reproductive and endocrine systems, and even causing cancer. Changes in the epigenome induced by the environment have been documented in diverse animal phyla, ranging from insects to rodents to humans.

  • Track 5-1Animal models in epigenetics research
  • Track 5-2Animal cloning epigenetics
  • Track 5-3Animal epigenetics examples
  • Track 5-4Animal epigenetics welfare

Plants are mainly depending on epigenetic processes for their proper functions. Plant epigenomes are more susceptible to environmental influence than those in animals. Epigenetic mechanisms are required for proper regulation while epi-alleles and epi-mutants, much like their genetic complements, describe changes in phenotype associated with distinct epigenetic circumstance. The study of epigenetics in plants is scientifically enthusiasm because epigenetics have long-standing importance in agriculture.

  • Track 6-1Growth and Development
  • Track 6-2Plant Transgenerational Epigenetics
  • Track 6-3Genotype and Phenotype
  • Track 6-4Epitranscriptomics

Cytogenetics is defined as the study of chromosomal structure, chromosome location and function in cells. Modern cytogenetic approaches are enable to precisely label the chromosomal location of any gene using different colored dots, examine cells from any type of tissue (even tumor cells), identify cells that have lost or gained a specific chromosome and determine whether specific regions of chromosomes have been lost or gained without ever looking at the chromosomes under a microscope.

  • Track 7-1Cancer cytogenetics
  • Track 7-2Karyotyping
  • Track 7-3Fluorescent in situ hybridization
  • Track 7-4Cytotaxonomy
  • Track 7-5Molecular cytogenetics

A chromosome is a DNA molecule in which either part or all of the genetic material is present. The condensation of chromatin is used to form the chromosome. Chromatin structure depends on several factors. The overall structure depends on the stage of the cell cycle. Human chromosomes can be divided into two type’s autosomes and allosome.

  • Track 8-1Chromatin packaging
  • Track 8-2Autosomal Chromosomes
  • Track 8-3Sexual Chromosomes
  • Track 8-4Chromosomal Segregation
  • Track 8-5Centromere and Telomere
  • Track 8-6Homo and Hetro Chromosome

Medical Epigenetics provides a comprehensive study of the importance of epigenetics to health management. Medical epigenetics is focusing on human systems, epigenetic diseases and treatments based on epigenetics-disorders and diseases. Medical epigenetics will cover all human systems relevant to epigenetic maladies. After the collection of genomic information and related data such as the levels of RNA, proteins and various metabolites that are crucial factors in medical, the genomic or personalized medicines are given to patients.

  • Track 9-1Methylation inhibiting drugs
  • Track 9-2Bromodomain and inhibitors
  • Track 9-3Histone acetylase (HAT) inhibitors
  • Track 9-4Protein methyltransferase inhibitors
  • Track 9-5Epigenetics meets endocrinology
  • Track 9-6Future Direction of Epigenetic Drugs

Epigenetic therapy is meant to use the drugs or epigenome-influencing techniques to treat medical states. Histone deactylases (HDACs), which modify histones, and DNA methyltransferases (DNMTs), which methylate DNA are the two enzymes that are important in epigenetic modifications and key targets for therapy with pharmaceutical drugs. Successful clinical studies carried out for both the enzymes. Epigenetic therapy has shown a strong effectiveness against hematological malignancies and solid tumors, gaining FDA approval for cutaneous T-cell lymphoma, ER-positive metastatic breast cancer, myelodysplastic syndrome, multiple myeloma, and peripheral T-cell lymphoma. Epigenetic therapy has proven successful for several types of cancer, including lung cancer, breast cancer, and lymphoma.

  • Track 10-1Fear
  • Track 10-2Anxiety
  • Track 10-3Trauma
  • Track 10-4Schizophrenia
  • Track 10-5Cardiac dysfunction
  • Track 10-6Pharmacokinetics epigenetics

Epigenetics in the nervous system is the study of the interaction between epigenetic process, which regulates gene expression without changing the deoxyribonucleic acid sequence, and the development, physiology and functions of the nervous system.

  • Track 11-1Histone Modifications in the Nervous System
  • Track 11-2Neurological disorders
  • Track 11-3Mania (Bipolar disorder)
  • Track 11-4Brain Disorders

Many of the computational, mathematical and statistical methods, ranging from data mining, sequence analysis, molecular interactions, to complex system-level simulations, have been reported in the literature. Efforts have been channeled into the text mining of epigenetic information, though development in this field is still at an early stage.

  • Track 12-1Precision Cancer Medicine
  • Track 12-2Epigenome data analysis
  • Track 12-3Epigenome prediction
  • Track 12-4Bioinformatics methods
  • Track 12-5Cancer informatics
  • Track 12-6Genome browsers

The study of epigenetic modifications on the genetic material of a cell is known as the epigenome. The field is parallel to genomics and proteomics, which are the study of the genome and proteome of a cell. Epigenomic maintenance (continuous process) is having an important role in maintaining the stability of eukaryotic genomes by taking part in crucial biological mechanisms. The plant flavones are the inhibiting epigenomic marks that cause cancers.

  • Track 13-1Human genome
  • Track 13-2Human genomics project
  • Track 13-3Plant genomics
  • Track 13-4Histone modification assay
  • Track 13-5Epigenomics compounds
  • Track 13-6Epigenomics compounds

Epigenetic changes have a large number of effects on the aging process. At various levels these epigenetic changes occur, including decreasing the levels of the core histones, changes in the patterns of histone post-translational modifications and DNA methylation, substitution of canonical histones with histone variants and changes the noncoding RNA expression (during both organismal aging and replicative senescence). The reversible nature of epigenetic information provides exciting path for therapeutic intervention in aging and age-associated diseases, including cancer.

  • Track 14-1Epigenetic clock
  • Track 14-2Epigenetic changes in aging
  • Track 14-3Histone modification changes during aging
  • Track 14-4Transgenerational epigenetic changes that affect aging
  • Track 14-5DNA methylation changes during aging

Transgenerational epigenetic inheritance is the transfer of information in organisms from parents to child that affects the characteristics of future generation without altering of the primary structure of DNA that is epigenetically. The term "epigenetic inheritance" may be used to describe information transfer in both the between cell and cell or organism and organism in organisms. Although in unicellular organisms these two levels of epigenetic inheritance are equivalent, they may have distinct mechanisms and evolutionary distinctions in multicellular organisms.

  • Track 15-1Deleterious effects
  • Track 15-2Putatively adaptive effects
  • Track 15-3Inheritance of epigenetic marks

As per the current excitement of field of genomics, we can easily forget that genes are simply small sections of DNA and part of much larger structures known as chromosomes.

  • Track 16-1Genetic diversity
  • Track 16-2Genetic variation
  • Track 16-3Genetic Drift
  • Track 16-4Chromosomal evolution in the Solanaceae
  • Track 16-5Migration and Mutation

Epigenetic mechanisms of pathological process have been implicated in several Central nervous system diseases, containing neurodevelopmental disorders of cognition where interruption in learning and memory are the primary clinical abnormality. Cognition generally refers to the mental processes comprising the gain of knowledge and the ability to comprehend the same. There are about 86 billion neurons in the human brain, which are from sets of large and small scale synaptic networks. These networks form structures that function as networks for learning and cognition.

  • Track 17-1Cognitive neuroepigenetics
  • Track 17-2Epigenetic code
  • Track 17-3Role of MAPK signaling in regulating epigenetic changes
  • Track 17-4Epigenetic interventions

Occasionally in genetic studies or in plant breeding there is advantage in manipulating no single genes but large arrays of associated genes. Such arrays may consist of all of the genes in a set of chromosomes, or on a single chromosome, or on a segment of chromosome.

  • Track 18-1Crop genetic engineering
  • Track 18-2Plant artificial chromosomes
  • Track 18-3Chromosome mechanics in plant breeding
  • Track 18-4Chromosomal abnormalities in plants

Epigenetics methylation refers to the addition of a methyl group (CH3) to the base cytosine (C) using covalently bond in the dinucleotide 5´-CpG-3´. Mostly the CpG dinucleotides in the human genome are methylated and the unmethylated CpGs are not distributed randomly, but are usually clumped together in ‘CpG islands, which are in the -region that facilitates transcription of a particular gene.

  • Track 19-1DNA methyltransferases
  • Track 19-2Molecular cloning
  • Track 19-3DNA methylation marks
  • Track 19-4Differentially methylated regions (DMRs)

Genome compaction is one the universal feature of cells which has emerged as a global regulator of gene expression. Compaction is maintained by multiple numbers of architectural proteins, long non-coding RNAs (lncRNAs), and regulatory DNA.

  • Track 20-1Chromatin print
  • Track 20-2Genetic interaction mapping
  • Track 20-3Functional genomics